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Article

Phosphoproteomic insights into GFPT2-Associated cellular phospho-signaling networks

5 Aug 2025

Abstract excerpt

The GFPT2 protein, also known as glutamine-fructose-6-phosphate aminotransferase 2, regulates glucose flux through the hexosamine biosynthesis pathway (HBP). It is primarily expressed in the spinal cord and central nervous system and is notably abundant in various cancers while being dysregulated in diabetes. Despite its significant role in critical diseases, the phospho-regulatory mechanisms governing GFPT2...

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PMID: 40808719
DOI: 10.1016/j.bbrep.2025.102196

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