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Article

Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice.

Biochemical and biophysical research communications - 30 May 2008

Yang Jian, Maika Shanna, Craddock Lauren, King Judy A, Liu Zhi-Mei

Abstract excerpt

To assess the metabolic effects of chronic activation of AMP-activated protein kinase (AMPK) in liver, we generated a new transgenic (Tg) mouse model expressing constitutively active (CA)-AMPK-alpha1 in liver. In the short-term activation, the TgCA-AMPK-alpha1 mice exhibited minimal phenotype, but the Tg liver had elevated sterol regulatory element-binding protein (SREBP)-2 mRNA level and a parallel increase in...

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Source

Identifiers

PMID: 18381066
DOI: 10.1016/j.bbrc.2008.03.094

Genes

UCP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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