Article
Assembly and infection efficacy of hepatitis B virus surface protein exchanges in 8 hepatitis D virus genotype isolates.
Journal of hepatology - 1 Aug 2021
Wang Wenshi, Lempp Florian A, Schlund Franziska, Walter Lisa, Decker Charlotte C, Zhang Zhenfeng, Ni Yi, Urban Stephan
Abstract excerpt
BACKGROUND & AIMS: Chronic HDV infections cause the most severe form of viral hepatitis. HDV requires HBV envelope proteins for hepatocyte entry, particle assembly and release. Eight HDV and 8 HBV genotypes have been identified. However, there are limited data on the replication competence of different genotypes and the effect that different HBV envelopes have on virion assembly and infectivity. METHODS: We...
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