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Decreased mRNA expression levels of DNA methyltransferases type 1 and 3A in systemic lupus erythematosus

27 Mar 2017

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic relapsing autoimmune disease characterized by the presence of autoantibodies directed against nuclear antigens and by chronic inflammation. Although the etiology of SLE remains unclear, the influence of environment factors, which is largely reflected by the epigenetic mechanisms, with DNA methylation changes in particular, is generally considered as main players in...

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PMID: 28349196
DOI: 10.1007/s00296-017-3711-8

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