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Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus

20 May 2011

Abstract excerpt

OBJECTIVES: To analyze associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase (DNMT1, DNMT3A, and DNMT3B) in patients with systemic lupus erythematosus (SLE) and to obtain a deeper understanding of the role that epigenetic mechanism may have on SLE. METHODS: The global DNA methylation profile in T cells from 34 patients with SLE and 23 healthy controls was assessed...

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PMID: 21595664
DOI: 10.1111/j.1365-4632.2010.04804.x

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