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Rapid and Reliable Genotyping of HLA-B*57:01 in Four Chinese Populations Using a Single-Tube Duplex Real-Time Polymerase Chain Reaction Assay.

AIDS research and human retroviruses - 1 Jul 2017

Han Min, Kang Xing, Liu Zhengbin, Zhang Tingting, Li Yanwei, Chen Chao, Wang Huijuan

Abstract excerpt

HLA-B*57:01 is strongly associated with severe adverse drug reaction induced by the anti-HIV drug abacavir (ABC) and antibiotic flucloxacillin. This study was dedicated to establishing a new method for HLA-B*57:01 genotyping and investigating the HLA-B*57:01 distribution pattern in four Chinese populations. A single-tube duplex real-time polymerase chain reaction (PCR) system was established by combining the...

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Identifiers

PMID: 28346841
DOI: 10.1089/aid.2016.0280

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