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Article

A single-tube multiplex real-time PCR for HLA-B*38:02 genotype by detecting highly specific SNPs.

Pharmacogenomics - 1 Jan 2023

Wang Fei, Li Wenqi, Wang Xuan, Luo Xiang, Dai Penggao

Abstract excerpt

Purpose: HLA-B*38:02 is closely related to carbimazole/methimazole-induced agranulocytosis. This study aimed to develop and validate a rapid and economical method for HLA-B*38:02 genotyping. Methods: A single-tube multiplex real-time PCR detection system comprising amplification refractory mutation system primers and TaqMan probes was established for HLA-B*38:02 genotyping. Sequence-based typing was applied to...

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PMID: 36661044
DOI: 10.2217/pgs-2022-0132

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