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A multiplex allele-specific real-time polymerase chain reaction assay for HLA-B*13:01 genotyping in four Chinese populations.

HLA - 1 Oct 2016

Liu Z, Chen G, Kang X, Han M, Chen R, Chen C, Wang H

Abstract excerpt

Human leukocyte antigen HLA-B*13:01 is identified currently as a marker of individual susceptibility to drug-induced hypersensitivity reaction, such as dapsone-induced hypersensitivity reactions (DIHRs) and trichloroethylene-induced dermatitis. Therefore, screening for the HLA-B*13:01 allele can assist clinics in identifying patients at risk of developing DIHRs. By combining the allele-specific primers with...

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PMID: 27558172
DOI: 10.1111/tan.12863

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