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Article

Detection of HLA-B*57:01 by real-time PCR: implementation into routine clinical practice and additional validation data.

Pharmacogenomics - 1 Feb 2014

Dello Russo Cinzia, Lisi Lucia, Fabbiani Massimiliano, Gagliardi Dimitri, Fanti Iuri, Di Giambenedetto Simona, Cauda Roberto, Navarra Pierluigi

Abstract excerpt

AIM: HLA-B*57:01 status needs to be determined before initiating abacavir therapy. We developed a pharmacogenetic real-time (Q)-PCR screening test using two sets of sequence specific primers. This test has been implemented into routine clinical practice. MATERIALS & METHODS: HIV-infected patients admitted at our University Hospital were thus genotyped using the above mentioned test. A panel of 80 DNA samples with...

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PMID: 24533711
DOI: 10.2217/pgs.13.242

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