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Article

Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01.

The pharmacogenomics journal - 1 Apr 2015

Cascella R, Strafella C, Ragazzo M, Zampatti S, Borgiani P, Gambardella S, Pirazzoli A, Novelli G, Giardina E

Abstract excerpt

One of the most successful applications of pharmacogenetics research is the genetic screening for HLA-B*57:01, strongly associated with an increased risk to develop hypersensitivity reaction in HIV-positive patients following abacavir administration. Taking into consideration the limits of current genotyping methodologies, we have developed and validated (150 buccal swabs) an inexpensive pharmacogenetic approach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25201286
DOI: 10.1038/tpj.2014.48
PMCID: PMC4381103

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Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01.PMID 25201286Read ↗

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