Article
Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein.
PLoS pathogens - 1 Mar 2013
Mänz Benjamin, Dornfeld Dominik, Götz Veronika, Zell Roland, Zimmermann Petra, Haller Otto, Kochs Georg, Schwemmle Martin
Abstract excerpt
The interferon-induced dynamin-like MxA GTPase restricts the replication of influenza A viruses. We identified adaptive mutations in the nucleoprotein (NP) of pandemic strains A/Brevig Mission/1/1918 (1918) and A/Hamburg/4/2009 (pH1N1) that confer MxA resistance. These resistance-associated amino acids in NP differ between the two strains but form a similar discrete surface-exposed cluster in the body domain of...
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