Article
Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells.
Molecular biology of the cell - 1 Dec 2023
Usman Olalekan H, Kumar Sampath, Walker Reddick R, Xie Gengqiang, Sumajit Hyeje C, Jalil AbdelAziz R, Ramakrishnan Subramanian, Dooling Lawrence J, Wang Yue Julia, Irianto Jerome
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is reported to be the third highest cause of cancer-related deaths in the United States. PDAC is known for its high proportion of stroma, which accounts for 90% of the tumor mass. The stroma is made up of extracellular matrix (ECM) and nonmalignant cells such as inflammatory cells, cancer-associated fibroblasts, and lymphatic and blood vessels. Here, we decoupled the...
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