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Article

Adapting clinical paradigms to the challenges of cancer clonal evolution.

The American journal of pathology - 1 Jun 2013

Murugaesu Nirupa, Chew Su Kit, Swanton Charles

Abstract excerpt

Emerging evidence suggests that cancer branched evolution may affect biomarker validation, clinical outcome, and emergence of drug resistance. The changing spatial and temporal nature of cancer subclonal architecture during the disease course suggests the need for longitudinal prospective studies of cancer evolution and robust and clinically implementable pathologic definitions of intratumor heterogeneity,...

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Identifiers

PMID: 23708210
DOI: 10.1016/j.ajpath.2013.02.026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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