Article
Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling.
British journal of cancer - 1 Apr 2021
Yaegashi Mizunori, Iwaya Takeshi, Sasaki Noriyuki, Fujita Masashi, Ju Zhenlin, Siwak Doris, Hachiya Tsuyoshi, Sato Kei, Endo Fumitaka, Kimura Toshimoto, Otsuka Koki, Sugimoto Ryo, Sugai Tamotsu, Liotta Lance, Lu Yiling, Mills Gordon B, Nakagawa Hidewaki, Nishizuka Satoshi S
Abstract excerpt
BACKGROUND: Circulating tumour DNA (ctDNA) is known as a tumour-specific personalised biomarker, but the mutation-selection criteria from heterogeneous tumours remain a challenge. METHODS: We conducted multiregional sequencing of 42 specimens from 14 colorectal tumours of 12 patients, including two double-cancer cases, to identify mutational heterogeneity to develop personalised ctDNA assays using 175 plasma...
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