Article
The KIF1A homolog Unc-104 is important for spontaneous release, postsynaptic density maturation and perisynaptic scaffold organization.
Scientific reports - 27 Mar 2017
Zhang Yao V, Hannan Shabab B, Kern Jeannine V, Stanchev Doychin T, Koç Baran, Jahn Thomas R, Rasse Tobias M
Abstract excerpt
The kinesin-3 family member KIF1A has been shown to be important for experience dependent neuroplasticity. In Drosophila, amorphic mutations in the KIF1A homolog unc-104 disrupt the formation of mature boutons. Disease associated KIF1A mutations have been associated with motor and sensory dysfunctions as well as non-syndromic intellectual disability in humans. A hypomorphic mutation in the forkhead-associated...
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