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Article

Mesothelin promoter variants are associated with increased soluble mesothelin-related peptide levels in asbestos-exposed individuals.

Occupational and environmental medicine - 1 Jun 2017

De Santi Chiara, Pucci Perla, Bonotti Alessandra, Melaiu Ombretta, Cipollini Monica, Silvestri Roberto, Vymetalkova Veronika, Barone Elisa, Paolicchi Elisa, Corrado Alda, Lepori Irene, Dell'Anno Irene, Pellè Lucia, Vodicka Pavel, Mutti Luciano, Foddis Rudy, Cristaudo Alfonso, Gemignani Federica, Landi Stefano

Abstract excerpt

BACKGROUND: Soluble mesothelin-related peptide (SMRP) is a promising diagnostic biomarker for malignant pleural mesothelioma (MPM), but various confounders hinder its usefulness in surveillance programmes. We previously showed that a single nucleotide polymorphism (SNP) within the 3'untranslated region (3'UTR) of the mesothelin (MSLN) gene could affect the levels of SMRP. OBJECTIVES: To focus on SNPs located...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28343162
DOI: 10.1136/oemed-2016-104024

Genes

MSLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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