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Article

A genetic variant of NLRP1 gene is associated with asbestos body burden in patients with malignant pleural mesothelioma.

Journal of toxicology and environmental health. Part A - 1 Jan 2018

Crovella S, Moura R R, Cappellani S, Celsi F, Trevisan E, Schneider M, Brollo A, Nicastro E M, Vita F, Finotto L, Zabucchi G, Borelli V

Abstract excerpt

The presence of asbestos bodies (ABs) in lung parenchyma is considered a histopathologic hallmark of past exposure to asbestos fibers, of which there was a population of longer fibers. The mechanisms underlying AB formation are complex, involving inflammatory responses and iron (Fe) metabolism. Thus, the responsiveness to AB formation is variable, with some individuals appearing to be poor AB formers. The aim of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29265930
DOI: 10.1080/15287394.2017.1416911

Genes

NLRP1

Variants

rs12150220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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