Article
Gene-asbestos interaction in malignant pleural mesothelioma susceptibility.
Carcinogenesis - 1 Oct 2015
Tunesi Sara, Ferrante Daniela, Mirabelli Dario, Andorno Silvano, Betti Marta, Fiorito Giovanni, Guarrera Simonetta, Casalone Elisabetta, Neri Monica, Ugolini Donatella, Bonassi Stefano, Matullo Giuseppe, Dianzani Irma, Magnani Corrado
Abstract excerpt
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, on average less than 10% of subjects highly exposed to asbestos develop MPM, suggesting the possible involvement of other risk factors. To identify the genetic factors that may modulate the risk of MPM, we conducted a gene-environment interaction analysis including asbestos exposure and 15...
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