Article
Genetic variants associated with increased risk of malignant pleural mesothelioma: a genome-wide association study.
PloS one - 1 Jan 2013
Matullo Giuseppe, Guarrera Simonetta, Betti Marta, Fiorito Giovanni, Ferrante Daniela, Voglino Floriana, Cadby Gemma, Di Gaetano Cornelia, Rosa Fabio, Russo Alessia, Hirvonen Ari, Casalone Elisabetta, Tunesi Sara, Padoan Marina, Giordano Mara, Aspesi Anna, Casadio Caterina, Ardissone Francesco, Ruffini Enrico, Betta Pier Giacomo, Libener Roberta, Guaschino Roberto, Piccolini Ezio, Neri Monica, Musk Arthur W B, de Klerk Nicholas H, Hui Jennie, Beilby John, James Alan L, Creaney Jenette, Robinson Bruce W, Mukherjee Sutapa, Palmer Lyle J, Mirabelli Dario, Ugolini Donatella, Bonassi Stefano, Magnani Corrado, Dianzani Irma
Abstract excerpt
Asbestos exposure is the main risk factor for malignant pleural mesothelioma (MPM), a rare aggressive tumor. Nevertheless, only 5-17% of those exposed to asbestos develop MPM, suggesting the involvement of other environmental and genetic risk factors. To identify the genetic risk factors that may contribute to the development of MPM, we conducted a genome-wide association study (GWAS; 370,000 genotyped SNPs, 5...
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