Article
Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.
Cell stem cell - 2 Jul 2015
Wu Haodi, Lee Jaecheol, Vincent Ludovic G, Wang Qingtong, Gu Mingxia, Lan Feng, Churko Jared M, Sallam Karim I, Matsa Elena, Sharma Arun, Gold Joseph D, Engler Adam J, Xiang Yang K, Bers Donald M, Wu Joseph C
Abstract excerpt
β-adrenergic signaling pathways mediate key aspects of cardiac function. Its dysregulation is associated with a range of cardiac diseases, including dilated cardiomyopathy (DCM). Previously, we established an iPSC model of familial DCM from patients with a mutation in TNNT2, a sarcomeric protein. Here, we found that the β-adrenergic agonist isoproterenol induced mature β-adrenergic signaling in iPSC-derived...
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