Article
KLF1 gene mutations cause borderline HbA(2).
Blood - 20 Oct 2011
Perseu Lucia, Satta Stefania, Moi Paolo, Demartis Franca Rosa, Manunza Laura, Sollaino Maria Carla, Barella Susanna, Cao Antonio, Galanello Renzo
Abstract excerpt
Increased hemoglobin A(2) (HbA(2); ie, levels > 3.9%) is the most important feature of β-thalassemia carriers. However, it is not uncommon to find persons with borderline HbA(2) (levels, 3.3%-3.8%), who pose a relevant screening problem. Several genotypes have been associated with borderline HbA(2), but sometimes the reasons for this unusual phenotype are unknown. In this paper, we report, for the first time,...
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