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Article

Prospective study of common variants in CX3CR1 and risk of macular degeneration: pooled analysis from 5 long-term studies.

JAMA ophthalmology - 1 Jan 2014

Schaumberg Debra A, Rose Lynda, DeAngelis Margaret M, Semba Richard D, Hageman Gregory S, Chasman Daniel I

Abstract excerpt

IMPORTANCE: The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been inconsistent and mostly limited to evaluation of 2 nonsynonymous variants, T280M (rs3732378) and V249I (rs3732379). OBJECTIVE: To determine if...

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Source

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Identifiers

PMID: 24287500
DOI: 10.1001/jamaophthalmol.2013.5506
PMCID: PMC4170669

Genes

CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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