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Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in mice

24 Mar 2017

Abstract excerpt

BACKGROUND: La Crosse Virus (LACV) is a primary cause of pediatric viral encephalitis in the USA and can result in severe clinical outcomes. Almost all cases of LACV encephalitis occur in children 16 years or younger, indicating an age-related susceptibility. This susceptibility is recapitulated in a mouse model where weanling (3 weeks old or younger) mice are susceptible to LACV-induced disease, and adults...

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PMID: 28340587
DOI: 10.1186/s12974-017-0836-3

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