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CD8+ T Cells Complement Antibodies in Protecting against Yellow Fever Virus

25 Dec 2014

Abstract excerpt

The attenuated yellow fever (YF) vaccine (YF-17D) was developed in the 1930s, yet little is known about the protective mechanisms underlying its efficiency. In this study, we analyzed the relative contribution of cell-mediated and humoral immunity to the vaccine-induced protection in a murine model of YF-17D infection. Using different strains of knockout mice, we found that CD4(+) T cells, B cells, and Abs are...

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PMID: 25539816
DOI: 10.4049/jimmunol.1402605

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