Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin-1alpha, tumor necrosis factor-alpha, transforming growth factor-beta and oncostatin M in human cardiac myocytes.

doi:10.1006/jmcc.2002.2117

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Plasminogen activator inhibitor 1 expression is regulated by the inflammatory mediators interleukin-1alpha, tumor necrosis factor-alpha, transforming growth factor-beta and oncostatin M in human cardiac myocytes.

Journal of molecular and cellular cardiology - 1 Dec 2002

Macfelda Karin, Weiss Thomas W, Kaun Christoph, Breuss Johannes M, Zorn Gerlinde, Oberndorfer Ulrich, Voegele-Kadletz Margit, Huber-Beckmann Renate, Ullrich Robert, Binder Bernd R, Losert Udo M, Maurer Gerald, Pacher Richard, Huber Kurt, Wojta Johann

Abstract excerpt

Accumulating evidence points towards a role for proteases and protease inhibitors in tissue remodelling and repair in a variety of organs. In particular-besides the matrix metalloprotease system-the plasminogen activator (PA)/plasmin system has been implicated in these processes in the heart. Urokinase type PA (u-PA) and PA inhibitor type 1 (PAI-1) seem to modulate cardiac rupture and infarct healing. In this...

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PMID: 12505065
DOI: 10.1006/jmcc.2002.2117

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