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Article

Cardiac macrophages adopt profibrotic/M2 phenotype in infarcted hearts: Role of urokinase plasminogen activator.

Journal of molecular and cellular cardiology - 1 Jul 2017

Carlson Signe, Helterline Deri, Asbe Laura, Dupras Sarah, Minami Elina, Farris Stephen, Stempien-Otero April

Abstract excerpt

BACKGROUND: Macrophages (mac) that over-express urokinase plasminogen activator (uPA) adopt a profibrotic M2 phenotype in the heart in association with cardiac fibrosis. We tested the hypothesis that cardiac macs are M2 polarized in infarcted mouse and human hearts and that polarization is dependent on mac-derived uPA. METHODS: Studies were performed using uninjured (UI) or infarcted (MI) hearts of uPA...

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Identifiers

PMID: 27262672
DOI: 10.1016/j.yjmcc.2016.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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