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Article

Plasminogen activator inhibitor-1 reduces cardiac fibrosis and promotes M2 macrophage polarization in inflammatory cardiomyopathy.

Basic research in cardiology - 11 Jan 2021

Baumeier Christian, Escher Felicitas, Aleshcheva Ganna, Pietsch Heiko, Schultheiss Heinz-Peter

Abstract excerpt

Plasminogen activator inhibitor-1 (PAI-1) has a cardioprotective function in mice by repressing cardiac fibrosis through TGF-β and plasminogen-mediated pathways. In addition it is known to be involved in the recruitment and polarization of monocytes/macrophages towards a M2 phenotype in cancer. Here, we investigated the expression of PAI-1 in human dilated cardiomyopathy (DCM) and inflammatory dilated...

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Identifiers

PMID: 33432417
DOI: 10.1007/s00395-020-00840-w
PMCID: PMC7801308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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