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Article

Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach.

International journal of molecular sciences - 18 Mar 2017

Eadon Michael T, Hause Ronald J, Stark Amy L, Cheng Ying-Hua, Wheeler Heather E, Burgess Kimberly S, Benson Eric A, Cunningham Patrick N, Bacallao Robert L, Dagher Pierre C, Skaar Todd C, Dolan M Eileen

Abstract excerpt

Colistin sulfate (polymixin E) is an antibiotic prescribed with increasing frequency for severe Gram-negative bacterial infections. As nephrotoxicity is a common side effect, the discovery of pharmacogenomic markers associated with toxicity would benefit the utility of this drug. Our objective was to identify genetic markers of colistin cytotoxicity that were also associated with expression of key proteins using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28335481
DOI: 10.3390/ijms18030661
PMCID: PMC5372673

Genes

HOXD10
TGIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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