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Article

Correlations between genetically predicted iron-supplement drug targets and inflammatory bowel disease: A Mendelian randomization study.

Medicine - 13 Jun 2025

Li Dong-Lin, Jiang Chuan, Guan Zhong-An, Ma Ling-Ling, Cui Wen-Wen

Abstract excerpt

This study investigates the causal relationship between genetically proxied iron-supplement drugs and inflammatory bowel disease (IBD) risk. After identifying 8 commonly used iron supplementation drugs based on the guidelines, a search for each of these drugs yielded 18 key regulatory targets and the locus information of each drug-targeted gene was obtained. Hemoglobin was selected as a biomarker downstream of...

Read the complete abstract on PubMed

Topics

Humans
Mendelian Randomization Analysis
Genome-Wide Association Study
Polymorphism, Single Nucleotide
Inflammatory Bowel Diseases
Dietary Supplements

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Crohn Disease

Colitis, Ulcerative

Iron

Hemoglobins

Source

Open in PubMed Open full text

Identifiers

PMID: 40527798
DOI: 10.1097/MD.0000000000042729
PMCID: PMC12173267

Genes

EGLN1
FEN1
POLB
FTH1
ITGB3
TFRC
TFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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