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Genetic predisposition and high exposure to colistin in the early treatment period as independent risk factors for colistin-induced nephrotoxicity.

Clinical and translational science - 1 Mar 2024

Mathew Sumith K, Chapla Aaron, Venkatesan Padmanaban, Eriyat Vishnu, Aruldhas Blessed Winston, Prabha Ratna, Neely Michael N, Rao Shoma V, Kandasamy Subramani, Mathew Binu Susan

Abstract excerpt

Colistin is known to cause nephrotoxicity due to its extensive reabsorption and accumulation in renal tubules. In vitro studies have identified the functional role of colistin transporters such as OCTN2, PEPT2, megalin, and P-glycoprotein. However, the role of these transporter gene variants in colistin-induced nephrotoxicity has not been studied. Utilizing targeted next-generation sequencing, we screened for...

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Identifiers

PMID: 38476095
DOI: 10.1111/cts.13764
PMCID: PMC10933594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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