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Article

DMET™ (Drug-Metabolizing Enzymes and Transporters) microarray analysis of colorectal cancer patients with severe 5-fluorouracil-induced toxicity.

Cancer chemotherapy and pharmacology - 1 Aug 2013

Rumiato Enrica, Boldrin Elisa, Amadori Alberto, Saggioro Daniela

Abstract excerpt

PURPOSE: 5-fluorouracil (5-FU) has been widely used since the 1980s, and it remains the backbone of many chemotherapeutic combination regimens. However, its use is often limited by the occurrence of severe toxicity. Although several reports have shown the detrimental effect of some dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS) gene polymorphisms in patients undergoing 5-FU-based...

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Source

Identifiers

PMID: 23760813
DOI: 10.1007/s00280-013-2210-1

Genes

DPYD
TYMS
CHST1
GSTM3

Provenance

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