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Article

Understanding Triple Negative Myeloproliferative Neoplasms and Identifying Molecular Drivers.

Current hematologic malignancy reports - 15 Jan 2026

Boldrini Valentina, Loscocco Giuseppe G, Guglielmelli Paola, Gangat Naseema, Vannucchi Alessandro M, Tefferi Ayalew

Abstract excerpt

PURPOSE OF REVIEW: Triple-negative (TN) myeloproliferative neoplasms (MPNs), defined by the absence of canonical driver JAK2, CALR and MPL mutations, represent a heterogeneous and still poorly understood subgroup of chronic myeloid neoplasms. This review summarizes current knowledge on characteristics and molecular landscape of TN MPNs. RECENT FINDINGS: Although TN MPNs share clinical and morphological features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41537939
DOI: 10.1007/s11899-026-00770-9

Genes

ASXL1
CALR
JAK2
MPL
SETBP1
SRSF2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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