Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.

PloS one - 1 Jan 2016

Cobolli Gigli Clementina, Scaramuzza Linda, Gandaglia Anna, Bellini Elisa, Gabaglio Marina, Parolaro Daniela, Kilstrup-Nielsen Charlotte, Landsberger Nicoletta, Bedogni Francesco

Abstract excerpt

MECP2 mutations cause a number of neurological disorders of which Rett syndrome (RTT) represents the most thoroughly analysed condition. Many Mecp2 mouse models have been generated through the years; their validity is demonstrated by the presence of a broad spectrum of phenotypes largely mimicking those manifested by RTT patients. These mouse models, between which the C57BL/6 Mecp2tm1.1Bird strain probably...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Background

Share to Methyl-CpG-Binding Protein 2

Share to Models, Animal

Share to Neurons

Share to Species Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 27097329
DOI: 10.1371/journal.pone.0153473
PMCID: PMC4838291

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.PMID 27097329Read ↗

Mouse models of Rett syndrome: from behavioural phenotyping to preclinical evaluation of new therapeutic approaches.Semantic proximity Read ↗

Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering.Semantic proximity Read ↗

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome.Semantic proximity Read ↗

Rett syndrome treatment in mouse models: searching for effective targets and strategies.Semantic proximity Read ↗

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome.Semantic proximity Read ↗

Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndromeSemantic proximity Read ↗

Sex differences in Mecp2-mutant Rett syndrome model mice and the impact of cellular mosaicism in phenotype development.Semantic proximity Read ↗

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.Semantic proximity Read ↗

MeCP2 dysfunction in humans and mice.Semantic proximity Read ↗

Breeding and maintenance of an Mecp2-deficient mouse model of Rett syndrome.Semantic proximity Read ↗

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model.Semantic proximity Read ↗

Comprehensive Analysis of GABAA-A1R Developmental Alterations in Rett Syndrome: Setting the Focus for Therapeutic Targets in the Time Frame of the Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.