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Article

Intra-individual purifying selection on mitochondrial DNA variants during human oogenesis.

Human reproduction (Oxford, England) - 1 May 2017

De Fanti Sara, Vicario Saverio, Lang Martin, Simone Domenico, Magli Cristina, Luiselli Donata, Gianaroli Luca, Romeo Giovanni

Abstract excerpt

STUDY QUESTION: Does selection for mtDNA mutations occur in human oocytes? SUMMARY ANSWER: We provide statistical evidence in favor of the existence of purifying selection for mtDNA mutations in human oocytes acting between the expulsion of the first and second polar bodies (PBs). WHAT IS KNOWN ALREADY: Several lines of evidence in Metazoa, including humans, indicate that variation within the germline of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28333293
DOI: 10.1093/humrep/dex051
PMCID: PMC5850138

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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