Article
Poor correlations in the levels of pathogenic mitochondrial DNA mutations in polar bodies versus oocytes and blastomeres in humans.
American journal of human genetics - 8 Apr 2011
Gigarel Nadine, Hesters Laetitia, Samuels David C, Monnot Sophie, Burlet Philippe, Kerbrat Violaine, Lamazou Frédéric, Benachi Alexandra, Frydman René, Feingold Josué, Rotig Agnes, Munnich Arnold, Bonnefont Jean-Paul, Frydman Nelly, Steffann Julie
Abstract excerpt
Because the mtDNA amount remains stable in the early embryo until uterine implantation, early human development is completely dependent on the mtDNA pool of the mature oocyte. Both quantitative and qualitative mtDNA defects therefore may negatively impact oocyte competence or early embryonic development. However, nothing is known about segregation of mutant and wild-type mtDNA molecules during human meiosis. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.