Article

Germline Selection by Meiosis Defends the Transmission of defective Mitochondria with mtDNA variants

2020-11-11

Abstract excerpt

<h4>SUMMARY</h4> Germline selection of mtDNA is vital in maternal inheritance of mtDNA, as it can eliminate severe mtDNA mutations. However, current evidence concerning germline selection at meiosis level comes from incomplete mtDNA sequencing in human first polar body (PB1), which lacks persuasion. Here, we found various variants, including pathogenic mutation sites, present on whole genome of mtDNA in human PB1...

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Literature Corpus work: 58824d32-f7c3-59a7-b702-70cf45e16069
DOI: 10.1101/2020.11.10.377390

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