Article
Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping.
Genes and immunity - 1 Mar 2017
Cyr D D, Allen A S, Du G-J, Ruffin F, Adams C, Thaden J T, Maskarinec S A, Souli M, Guo S, Dykxhoorn D M, Scott W K, Fowler V G
Abstract excerpt
The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were...
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