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Article

Elevated risk of invasive group A streptococcal disease and host genetic variation in the human leucocyte antigen locus.

Genes and immunity - 1 Jan 2020

Parks Tom, Elliott Katherine, Lamagni Theresa, Auckland Kathryn, Mentzer Alexander J, Guy Rebecca, Cartledge Doreen, Strakova Lenka, Connor Daniel O', Pollard Andrew J, Neville Matthew J, Mahajan Anubha, Ashrafian Houman, Chapman Stephen J, Hill Adrian V S, Sriskandan Shiranee, Knight Julian C

Abstract excerpt

Invasive group A streptococcal (GAS) disease is uncommon but carries a high case-fatality rate relative to other infectious diseases. Given the ubiquity of mild GAS infections, it remains unclear why healthy individuals will occasionally develop life-threatening infections, raising the possibility of host genetic predisposition. Here, we present the results of a case-control study including 43 invasive GAS cases...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31462703
DOI: 10.1038/s41435-019-0082-z
PMCID: PMC7039814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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