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Article

The NCA-1 and NCA-2 Ion Channels Function Downstream of Gq and Rho To Regulate Locomotion in Caenorhabditis elegans.

Genetics - 1 May 2017

Topalidou Irini, Chen Pin-An, Cooper Kirsten, Watanabe Shigeki, Jorgensen Erik M, Ailion Michael

Abstract excerpt

The heterotrimeric G protein Gq positively regulates neuronal activity and synaptic transmission. Previously, the Rho guanine nucleotide exchange factor Trio was identified as a direct effector of Gq that acts in parallel to the canonical Gq effector phospholipase C. Here, we examine how Trio and Rho act to stimulate neuronal activity downstream of Gq in the nematode Caenorhabditis elegans Through two forward...

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Identifiers

PMID: 28325749
DOI: 10.1534/genetics.116.198820
PMCID: PMC5419474

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NALCN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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