Article
PKN-1, a homologue of mammalian PKN, is involved in the regulation of muscle contraction and force transmission in C. elegans.
Journal of molecular biology - 25 Mar 2011
Qadota Hiroshi, Miyauchi Takayuki, Nahabedian John F, Stirman Jeffrey N, Lu Hang, Amano Mutsuki, Benian Guy M, Kaibuchi Kozo
Abstract excerpt
To examine the in vivo functions of protein kinase N (PKN), one of the effectors of Rho small guanosine triphosphatases (GTPases), we used the nematode Caenorhabditis elegans as a genetic model system. We identified a C. elegans homologue (pkn-1) of mammalian PKN and confirmed direct binding to C. elegans Rho small GTPases. Using a green fluorescent protein reporter, we showed that pkn-1 is mainly expressed in...
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