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The G protein alpha Chaperone and Guanine-Nucleotide Exchange Factor RIC-8 Regulates Cilia Morphogenesis in <i>Caenorhabditis elegans</i> Sensory Neurons

2023-08-26

Abstract excerpt

Heterotrimeric G (αβγ) proteins are canonical transducers of G-protein-coupled receptor (GPCR) signaling and play critical roles in communication between cells and their environment. Many GPCRs and heterotrimeric G proteins localize to primary cilia and modulate cilia morphology via mechanisms that are not well understood. Here, we show that RIC-8, a cytosolic guanine nucleotide exchange factor (GEF) and chaperone...

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Literature Corpus work
7e076a2a-6ad1-5a85-a771-2f3ec54a029c
DOI
10.1101/2023.08.25.554856
Open publication

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