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Article

Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans.

Genes & development - 1 Nov 2007

Williams Stacey L, Lutz Susanne, Charlie Nicole K, Vettel Christiane, Ailion Michael, Coco Cassandra, Tesmer John J G, Jorgensen Erik M, Wieland Thomas, Miller Kenneth G

Abstract excerpt

The Galpha(q) pathway is essential for animal life and is a central pathway for driving locomotion, egg laying, and growth in Caenorhabditis elegans, where it exerts its effects through EGL-8 (phospholipase Cbeta [PLCbeta]) and at least one other effector. To find the missing effector, we performed forward genetic screens to suppress the slow growth and hyperactive behaviors of mutants with an overactive...

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Identifiers

PMID: 17942708
DOI: 10.1101/gad.1592007
PMCID: PMC2045128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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