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Article

A non-cell autonomous mouse model of CNS haemangioblastoma mediated by mutant KRAS.

Scientific reports - 21 Mar 2017

Bao Leyuan, Al-Assar Osama, Drynan Lesley F, Arends Mark J, Tyers Pam, Barker Roger A, Rabbitts Terence H

Abstract excerpt

Haemangioblastoma is a rare malignancy of the CNS where vascular proliferation causes lesions due to endothelial propagation. We found that conditionally expressing mutant Kras, using Rag1-Cre, gave rise to CNS haemangioblastoma in the cortex and cerebellum in mice that present with highly vascular tumours with stromal cells similar to human haemangioblastomas. The aberrant haemangioblastoma endothelial cells do...

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Identifiers

PMID: 28322325
DOI: 10.1038/srep44899
PMCID: PMC5359595

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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