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Article

Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.

The EMBO journal - 6 Jan 2010

Jacques Thomas S, Swales Alexander, Brzozowski Monika J, Henriquez Nico V, Linehan Jacqueline M, Mirzadeh Zaman, O' Malley Catherine, Naumann Heike, Alvarez-Buylla Arturo, Brandner Sebastian

Abstract excerpt

It has been suggested that intrinsic brain tumours originate from a neural stem/progenitor cell population in the subventricular zone of the post-natal brain. However, the influence of the initial genetic mutation on the phenotype as well as the contribution of mature astrocytes to the formation of brain tumours is still not understood. We deleted Rb/p53, Rb/p53/PTEN or PTEN/p53 in adult subventricular stem...

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Share to Adult Stem Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Retinoblastoma

Share to Glial Fibrillary Acidic Protein

Share to Glioma

Share to Models, Neurological

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Share to PTEN Phosphohydrolase

Source

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Identifiers

PMID: 19927122
DOI: 10.1038/emboj.2009.327
PMCID: PMC2808375

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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