Article
Genetically engineered mouse models of craniopharyngioma: an opportunity for therapy development and understanding of tumor biology
17 Apr 2017
Abstract excerpt
Adamantinomatous craniopharyngioma (ACP) is the commonest tumor of the sellar region in childhood. Two genetically engineered mouse models have been developed and are giving valuable insights into ACP biology. These models have identified novel pathways activated in tumors, revealed an important function of paracrine signalling and extended conventional theories about the role of organ-specific stem cells in...
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