Article
Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization.
Circulation. Cardiovascular genetics - 1 Apr 2017
Haitjema Saskia, Meddens Claartje A, van der Laan Sander W, Kofink Daniel, Harakalova Magdalena, Tragante Vinicius, Foroughi Asl Hassan, van Setten Jessica, Brandt Maarten M, Bis Joshua C, O'Donnell Christopher, Cheng Caroline, Hoefer Imo E, Waltenberger Johannes, Biessen Erik, Jukema J Wouter, Doevendans Pieter A F M, Nieuwenhuis Edward E S, Erdmann Jeanette, Björkegren Johan L M, Pasterkamp Gerard, Asselbergs Folkert W, den Ruijter Hester M, Mokry Michal
Abstract excerpt
BACKGROUND: As genome-wide association efforts, such as CARDIoGRAM and METASTROKE, are ongoing to reveal susceptibility loci for their underlying disease-atherosclerotic disease-identification of candidate genes explaining the associations of these loci has proven the main challenge. Many disease susceptibility loci colocalize with DNA regulatory elements, which influence gene expression through chromatin...
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