Article
Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima-Media Thickness: The Cohort on Diabetes and Atherosclerosis Maastricht (CODAM) Study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2016
Hertle Elisabeth, Arts Ilja C W, van der Kallen Carla J H, Feskens Edith J M, Schalkwijk Casper G, Hoffmann-Petersen Ingeborg T, Thiel Steffen, Stehouwer Coen D A, van Greevenbroek Marleen M J
Abstract excerpt
OBJECTIVE: Previous studies suggested that the lectin-complement pathway plays a complex role in cardiovascular disease (CVD). To date, no prospective human studies have investigated the relationship between the initiating factor of the lectin pathway, that is, mannose-binding lectin (MBL), and low-grade inflammation, endothelial dysfunction, or carotid intima-media thickness (cIMT). Moreover, MBL-associated...
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