Article
Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship.
The Journal of clinical endocrinology and metabolism - 1 Dec 2017
Borné Yan, Muhammad Iram Faqir, Lorés-Motta Laura, Hedblad Bo, Nilsson Peter M, Melander Olle, de Jong Eiko K, Blom Anna M, den Hollander Anneke I, Engström Gunnar
Abstract excerpt
Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants. Methods: C3 was analyzed in plasma from 4368 nondiabetic subjects, 46 to 68 years old, from the Malmö Diet and Cancer Study. Incidence of diabetes was...
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