Article
Complement C3 Associates With Incidence of Diabetes, but No Evidence of a Causal Relationship.
The Journal of clinical endocrinology and metabolism - 1 Dec 2017
Borné Yan, Muhammad Iram Faqir, Lorés-Motta Laura, Hedblad Bo, Nilsson Peter M, Melander Olle, de Jong Eiko K, Blom Anna M, den Hollander Anneke I, Engström Gunnar
Abstract excerpt
Purpose: This study explored whether complement factor 3 (C3) in plasma is associated with incidence of diabetes in a population-based cohort. We also identified genetic variants related to C3 and explored whether C3 and diabetes share common genetic determinants. Methods: C3 was analyzed in plasma from 4368 nondiabetic subjects, 46 to 68 years old, from the Malmö Diet and Cancer Study. Incidence of diabetes was...
Topics
- Adaptor Proteins, Signal Transducing
- Aged
- Biomarkers
- Complement C3
- Complement Factor H
- Diabetes Mellitus
- Diet
- Female
- Follow-Up Studies
- Genetic Variation
- Genome-Wide Association Study
- Genotype
- Humans