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Article

Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.

The International journal of biological markers - 24 Jul 2017

Al Zoubi Mazhar Salim, Zavaglia Katia, Mazanti Chiara, Al Hamad Mohammad, Al Batayneh Khalid, Aljabali Alaa A A, Bevilacqua Generoso

Abstract excerpt

BACKGROUND: Genotoxic factors, including ionizing radiation and oxidative stress, are associated with genomic instability and development of breast cancer (BC). The homologous recombination DNA repair (HRR) pathway, base excision repair (BER) mechanism, and antioxidative enzymes are required as defense mechanisms against these DNA damaging agents. GSTP1, XRCC1, XRCC3 and RAD51 proteins are essential components of...

Read the complete abstract on PubMed

Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28315507
DOI: 10.5301/ijbm.5000258

Genes

XRCC3
RAD51
GSTP1
XRCC1

Variants

rs1799794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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