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Article

Intratumor heterogeneity in hepatocellular carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2015

Friemel Juliane, Rechsteiner Markus, Frick Lukas, Böhm Friederike, Struckmann Kirsten, Egger Michèle, Moch Holger, Heikenwalder Mathias, Weber Achim

Abstract excerpt

PURPOSE: Morphologic intratumor heterogeneity is well known to exist in hepatocellular carcinoma (HCC), but very few systematic analyses of this phenomenon have been performed. The aim of this study was to comprehensively characterize morphologic intratumor heterogeneity in HCC. Also, taken into account were well-known immunohistochemical markers and molecular changes in liver cells that are considered in...

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Source

Identifiers

PMID: 25248380
DOI: 10.1158/1078-0432.CCR-14-0122

Genes

CTNNB1
AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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